Abcam, ab307711, Anti-Kv4.2/KCND2 antibody [EPR26384-89] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Kv4.2/KCND2 antibody. Carrier free. Suitable for mIHC, WB, IHC-P, IHC-Fr, Flow Cyt (Intra), IP and reacts with Rat, Mouse, Recombinant fragment - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26384-89,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:IHC-P, IP, mIHC, IHC-Fr, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv4.2 also known as KCND2 is a voltage-gated potassium channel subunit that plays an important role in controlling the electrical activity of neurons. This protein has a molecular mass of approximately 74 kDa. Kv4.2 is expressed mainly in the brain especially in the hippocampus and cortex regions. The channel regulates the flow of potassium ions across the cell membrane which is essential for maintaining the resting membrane potential and modulating action potentials.
Biological function summary
The Kv4.2 protein contributes to the transient outward potassium current known as I_A. It often associates with other accessory proteins like KChIP and DPP10 to form functional Kv4.2 channel complexes. These complexes are critical in shaping the signal transmission in neurons affecting synaptic plasticity and neuronal excitability. Kv4.2's action impacts the duration and frequency of neuronal firing influencing functions such as memory and learning.
Pathways
Kv4.2 is integral to the regulation of neuronal excitability in the context of signal transduction pathways. One well-studied pathway involves its role in the MAPK/ERK signaling cascade where Kv4.2 undergoes phosphorylation events that fine-tune its activity. This pathway includes proteins like ERK which interacts with Kv4.2 to affect how neurons respond to synaptic inputs. Kv4.2 is also interconnected with CaMKII signaling which modulates its trafficking and expression in neurons.
Alterations in Kv4.2 expression or function relate to neurological conditions such as epilepsy and spinocerebellar ataxia. In epilepsy abnormal Kv4.2 channel activity can lead to hyperexcitability of neurons contributing to seizure development. Interconnections with proteins like Nav1.1 influence these pathological conditions as they also regulate neuronal excitability. Furthermore mutations in Kv4.2 can disrupt normal neuronal signaling which could be implicated in spinocerebellar ataxia contributing to the range of motor coordination symptoms seen in these patients.