Abcam, ab307781, ioGlutamatergic Neurons TDP-43 M337V homozygous - Human iPSC derived cells

Size: 1000000Cells / vial / 5000000Cells / vial
ioGlutamatergic Neurons TDP-43 M337V homozygous - Human iPSC derived cells available to order. Wild type ioGlutamatergic Neurons (ab303447) form the genetically matched control for the ioGlutamatergic Neurons TDP-43 M337V homozygous disease model. - Concentration: 1 million cells/vial or 5 million cells/vial
Key facts
Species or organism:Human,
Form:LiquidSee storage information

Product details:
Wild type ioGlutamatergic Neurons (
ab303447
) form the genetically matched control for the ioGlutamatergic Neurons TDP-43 M337V homozygous disease model. This physiologically-relevant isogenic pairing offers a powerful next generation model to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in research and drug discovery.
ioGlutamatergic Neurons TDP-43 M337V homozygous are ioGlutamatergic Neurons carrying a genetically engineered M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP-43). ioGlutamatergic Neurons TDP-43 M337V homozygous have been reprogrammed from human iPSCs using opti-ox
technology, a precise reprogramming technology.
Human stem cells, within days, convert consistently into mature, functional glutamatergic neurons providing a high quality human model for the study of ALS and FTD.
ioGlutamatergic Neurons TDP-43 M337V homozygous express pan-neuronal and glutamatergic markers TUBB3, MAP2 and VGLUT2 by day 11.
This disease model offers a fast and easy-to-use system for investigations into the impact of gene function on disease progression against an isogenic control.
A heterozygous disease model is also available (
ab307782
In partnership with bit.bio
Karyotype:
Normal
Seeding Density:
30,000 cells/cm
Seeding compatibility:
6-, 12-, 24-, 96- and 384-well compatible
Quality control:
ICC and gene expression analysis
Research applications:
Academic research, Drug development, Neurotoxicology, Genetic screening (e.g. CRISPR screening).
This product is subject to limited use licenses from iPS Academia Japan Inc, TET Systems GmbH, ERS Genomics Limited and Sigma-Aldrich Co. LLC and is developed with Bit Bio patented technology. For full details of the licenses and patents please refer to our
limited use license and patent pages

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C