Abcam, ab307819, Anti-METTL15 antibody [EPR25213-46]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal METTL15 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25213-46,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL15 also known as methyltransferase-like protein 15 is a methyltransferase enzyme with a molecular mass of approximately 50 kDa. This enzyme catalyzes the transfer of methyl groups and is important in the modulation of RNA function. It is highly expressed in human tissues particularly in the liver and brain indicating its involvement in vital cellular processes. METTL15 is responsible for methylation of adenine residues in ribosomal RNA (rRNA) which is important for ribosome function and maturation.
Biological function summary
METTL15 influences gene expression and translation fidelity by modifying rRNA within the 60S subunit of ribosomes. Through its action METTL15 helps stabilize ribosomal structure assisting in accurate protein synthesis. While METTL15 acts independently its functions are interconnected with other methyltransferases involved in RNA and DNA modification. The precise control of ribosomal methylation is vital for cellular homeostasis and protein synthesis efficiency.
Pathways
METTL15 contributes significantly to ribosome biogenesis and protein translation pathways. It influences the ribosome assembly process integrating into pathways critical for cell growth and proliferation. METTL15's functions relate closely to those of proteins like METTL3 and METTL14 which also partake in RNA methylation processes. Together these proteins interact in pathways that regulate gene expression and cellular response to growth signals.
METTL15 has been implicated in cancer and neurodevelopmental disorders. Altered expression of METTL15 can disrupt normal ribosomal function contributing to tumorigenesis and affecting neuronal development. Its role in cancer is often discussed alongside METTL3 as both are involved in RNA methylation processes linking to oncogenesis. Understanding METTL15's activity in these conditions could help develop targeted therapeutic strategies.