Abcam, ab307967, Anti-TRIM46 antibody [EPR26957-34]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TRIM46 antibody. Suitable for mIHC, WB, IHC-P, Flow Cyt (Intra), IHC-Fr, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26957-34,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-P, mIHC, Flow Cyt (Intra), ICC/IF, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIM46 also known as Tripartite Motif Containing 46 functions as a microtubule-organizing protein in the nervous system. It weighs approximately 82 kDa. This protein plays a role in stabilizing the microtubule network and is expressed mainly in neuronal cells and tissues. TRIM46 supports axon initiation and proper neuronal polarity by anchoring microtubules contributing to the organization of the axon initial segment.
Biological function summary
TRIM46 is involved in the regulation of microtubule dynamics. It associates with microtubule-associated proteins to promote stability and organization within neurons. Although not known to be part of a large complex TRIM46 interacts with proteins like EB1 to facilitate microtubule bundle formation. These interactions are important for axon guidance and neural signaling.
Pathways
TRIM46 participates in axon guidance and neural development pathways. It engages with the MAP kinase signaling pathway influencing cellular responses to growth factors. Additionally it relates to the Wnt signaling pathway where it's connected with proteins such as Dishevelled and β-catenin impacting neural patterning and development.
Deficiencies in TRIM46 have links to neurodevelopmental disorders and neurodegenerative diseases. Alterations in TRIM46 expression associate with autism spectrum disorders affecting neural connectivity and signaling. The protein also connects with Tau a protein implicated in Alzheimer's disease suggesting a role in microtubule-related neuronal dysfunction.