Abcam, ab308018, Anti-APJ Receptor antibody [RP23040146]

Size: 100µg
Rabbit Recombinant Multiclonal APJ antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Human APLNR.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040146,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human APLNR. Database linkP35414

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The APJ Receptor also known as the Apelin Receptor (APLNR) is a G protein-coupled receptor with a molecular mass of approximately 42 kDa. You find APJ Receptor highly expressed in tissues like the brain heart and lungs. It acts as a receptor for the peptides called apelin and elabela playing a critical role in signaling processes across various tissues. The receptor demonstrates complex mechanical actions by coupling with G proteins to inhibit adenylate cyclase activity and regulate other intracellular signaling pathways.
Biological function summary
The APJ Receptor influences cardiovascular function fluid homeostasis and energy metabolism. It does not form a part of a larger receptor complex but collaborates closely with other proteins within cellular networks. APJ Receptor engagement by apelin or elabela modulates blood pressure cardiac contractility and fluid balance underlying its important role in cardiovascular and renal systems. Therefore this receptor contributes significantly to maintaining physiological homeostasis.
Pathways
The APJ Receptor is integral to the Apelin signaling pathway known to influence cardiac function and embryonic development. It interacts with proteins such as the angiotensin receptor which also participates in regulation of blood pressure. Additionally APJ Receptor involvement in the PI3K-Akt signaling pathway affects cell survival and growth allowing it to intersect with pathways involved in various physiological processes.
APJ Receptor has connections to conditions like heart failure and pulmonary hypertension. Altered APJ Receptor function contributes to these diseases through its effect on cardiac and vascular systems. Moreover interactions between APJ Receptor and proteins such as endothelin receptors highlight its role in the progression of pulmonary hypertension highlighting the receptor as a potential therapeutic target in cardiovascular disease management.