Abcam, ab308119, Anti-Jarid2 antibody [RP23040193]

Size: 100µg
Rabbit Recombinant Multiclonal Jarid2 antibody. Suitable for ICC/IF, WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human JARID2.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040193,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human JARID2.Q92833

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Jarid2 also known as Jumonji or Jumonji AT-rich interactive domain 2 serves important functions in chromatin dynamics. It is a protein with a mass of approximately 125 kDa and plays a role as a regulatory factor in gene expression. Jarid2 expresses across several tissues particularly in those undergoing developmental processes such as the heart and central nervous system. The protein helps to recruit other proteins to chromatin impacting the regulation of gene activity.
Biological function summary
Jarid2 interacts with the polycomb repressive complex 2 (PRC2) which modulates chromatin structure to suppress gene transcription. This interaction is key for the protein's role in epigenetic regulation. As a component of PRC2 Jarid2 influences the methylation of histone H3 at lysine 27 (H3K27) a modification critical for controlling developmental genes' expression. Its function ensures proper regulation of gene programs that affect cell fate decisions during embryogenesis.
Pathways
Jarid2 integrates into the gene silencing pathways involving PRC2 influencing pathways like the Wnt/β-catenin signaling pathway. This influence occurs by modulating target genes that PRC2 controls such as those involved in cellular differentiation. Additionally it relates to proteins such as Ezh2 another PRC2 member. Together these components maintain repression of genes impacting cell proliferation and differentiation.
Jarid2 proves significant in conditions like cardiac hypertrophy and certain cancers. Its deregulation may lead to altered expression of genes necessary for cardiac muscle cell size and function contributing to hypertrophy. In cancer changes in Jarid2 expression or function can disrupt normal growth control as seen in interactions with proteins like Suz12 another PRC2 associate. Understanding these connections helps to outline potential therapeutic targets for intervention.