Abcam, ab308133, Anti-KLF17 antibody [RP23040191]

Size: 100µg
Rabbit Recombinant Multiclonal KLF17 antibody. Suitable for WB and reacts with Mouse, Rat samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF17.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040191,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human KLF17.Q5JT82

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF17 also known as Krüppel-like factor 17 is a zinc-finger transcription factor with a mass of approximately 35 kDa. This protein plays a role in DNA-binding and regulation of transcription. It regulates the expression of target genes by binding to GC-rich regions. Researchers have observed KLF17 expression in various tissues with notable levels in the reproductive organs such as the ovary and testis as well as in embryonic tissues which indicates its involvement in reproductive biology and development.
Biological function summary
KLF17 influences cellular processes by modulating the expression of genes involved in cell differentiation and proliferation. It functions primarily as a transcriptional repressor acting independently and not as part of a larger multiprotein complex. Its regulatory role affects key cellular functions contributing to the control of epithelial-mesenchymal transition (EMT) which is critical during embryogenesis and cancer metastasis.
Pathways
KLF17 plays a significant role in the TGF-β signaling pathway which is important in numerous cellular functions such as growth and differentiation. KLF17 interacts with other transcription factors like SNAIL and TWIST influencing pathways that control EMT and metastasis. This regulation within TGF-β signaling highlights KLF17's role in maintaining cellular architecture and regulating processes critical to tissue development and disease progression.
KLF17 shows a connection to cancer and fibrosis. Researchers have identified its involvement in the suppression of metastasis in several cancers including breast cancer by interacting with proteins like E-cadherin which maintain cell adhesion. In fibrosis alterations in KLF17 expression can disrupt normal tissue repair processes exacerbating the progression of fibrotic diseases by interacting with mediators involved in the TGF-β signaling pathway.