Abcam, ab308136, Anti-Synaptojanin 1 antibody [RP23040243]

Size: 100µg
Rabbit Recombinant Multiclonal Synaptojanin antibody. Suitable for WB, IHC-Fr and reacts with Rat, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human SYNJ1.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040243,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SYNJ1.O43426

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptojanin also known as SYNJ is a phosphoinositide phosphatase enzyme with a typical molecular mass of around 150 kDa. It functions mechanically by dephosphorylating phosphatidylinositol phosphates at various positions playing an important role in membrane curvature and endocytosis. Its expression is remarkably high in the brain especially in nerve terminals where it assists in synaptic vesicle recycling and neurotransmitter release. Synaptojanin expression also occurs in other tissues but at lower levels.
Biological function summary
Synaptojanin modulates synaptic function and plasticity through its role in lipid metabolism. It is part of a complex with endocytic proteins such as endophilin and dynamin which facilitates the uncoating of clathrin-coated vesicles following endocytosis. This complex action is important for maintaining synaptic efficiency and adaptability especially during high rates of synaptic activity. The disruption of synaptojanin's role affects the proper balance of phospholipids impacting neural communication and function.
Pathways
Synaptojanin plays a significant role in the phosphoinositide signaling and endocytic pathways. It works closely with other proteins like phosphatidylinositol-45-bisphosphate (PIP2) and adaptor protein 2 regulating membrane trafficking and the recycling of synaptic vesicles. These pathways are central to maintaining cellular homeostasis and ensuring neurotransmitter release and recycling occur effectively allowing cells to respond swiftly to dynamic signaling requirements.
Researchers link synaptojanin to neurological conditions like Parkinson's disease and Charcot-Marie-Tooth disease. Mutations in synaptojanin or its interaction partners such as endophilin have been shown to disrupt synaptic vesicle reformation leading to neurodegeneration. Studies suggest that variants in synaptojanin can result in synaptic dysfunction contributing to the pathophysiology of these disorders. Understanding synaptojanin's function helps in the development of therapeutic strategies for related neurodegenerative diseases.