Abcam, ab308162, Anti-ACSL1 antibody [HL1530]

Size: 100µL
Rabbit Recombinant Monoclonal ACSL1 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ACSL1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1530,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ACSL1. The exact immunogen used to generate this antibody is proprietary information.P33121

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The enzyme ACSL1 known as Acyl-CoA synthetase long-chain family member 1 plays an important role in lipid metabolism by converting free long-chain fatty acids into fatty acyl-CoA esters. This reaction is essential for the β-oxidation and synthesis of complex lipids. ACSL1 has an approximate mass of 78 kDa and is expressed in tissues with high metabolic activity including the liver heart and adipose tissue. The enzyme functions by regulating the cellular levels of fatty acids and their derivatives significantly impacting energy homeostasis.
Biological function summary
ACSL1 affects energy production and lipid storage by activating fatty acids making them substrates for metabolic processes. It is not only an independent enzyme but also works with other lipid-metabolizing enzymes to form complexes. This involvement in the dynamic regulation of lipid utilization and storage influences cellular energy balance and metabolic flexibility. ACSL1 also associates with peroxisomes contributing to its functions in lipid metabolism and organelle integrity.
Pathways
ACSL1 holds a significant position in the fatty acid metabolism and PPAR signaling pathways. It interacts with enzymes like CPT1 important for transporting activated fatty acids into mitochondria for β-oxidation highlighting its integral role in energy harvesting from lipids. This participation in essential metabolic pathways demonstrates ACSL1's contribution to maintaining cellular energy and lipid balance.
ACSL1 links to metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. Overexpression or aberrant function of ACSL1 can disrupt normal lipid homeostasis contributing to abnormal lipid accumulation and metabolic dysregulation. The enzyme also associates with SREBP-1 a regulator of lipid synthesis indicating its involvement in lipid-related disorders. Researching ACSL1 helps understand its impact on lipid metabolism-related pathologies.