Abcam, ab308175, Anti-NDUFV1 antibody [HL1600]

Size: 100µL
Rabbit Recombinant Monoclonal NDUFV1 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human NDUFV1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1600,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NDUFV1. The exact immunogen used to generate this antibody is proprietary information.P49821

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFV1 also known as NADH-ubiquinone oxidoreductase 51 kDa subunit plays a mechanical role in the electron transport chain. It has a molecular mass of approximately 51 kDa. The protein is an integral part of Complex I or NADH:ubiquinone oxidoreductase located in the inner mitochondrial membrane. NDUFV1 shows expression across various tissues with higher levels found in metabolically active tissues like skeletal muscle and heart.
Biological function summary
NDUFV1 participates in oxidative phosphorylation within cells. This protein functions as a core subunit of Complex I which is the first enzyme in the mitochondrial respiratory chain. NDUFV1 has a role in transferring electrons from NADH to ubiquinone an essential step for energy production. The efficient operation of Complex I affects ATP synthesis which is necessary for many cellular processes.
Pathways
NDUFV1 is central to the energy production in mitochondria. It is important for the oxidative phosphorylation pathway and is involved in maintaining the proton gradient across the inner mitochondrial membrane. This protein closely interacts with other subunits of Complex I like NDUFS1 and has significant synergy with them in electron transfer processes. Its activity is indispensable for proper cellular respiration and energy metabolism.
NDUFV1 mutations link to mitochondrial diseases such as Leigh syndrome and some cases of Complex I deficiency. In patients with these conditions there are disruptions in ATP production due to impaired electron transport chain function. The protein may also be involved in some forms of neurodegenerative diseases where mitochondrial dysfunction plays a role. NDUFS1 and other Complex I subunits often show associations with these disorders highlighting the importance of NDUFV1 in neuromuscular and metabolic health.