Abcam, ab308260, Anti-Arx antibody [EPR27481-32]

Size: 20µL / 100µL / 1mL
Anti-Arx antibody [EPR27481-32] (ab308260) is a rabbit monoclonal antibody detecting Arx in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC/IF, mIHC . Suitable for Human, Mouse, Rat . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27481-32,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:mIHC, IHC-P, WB, Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Arx antibody [EPR27481-32] (ab308260) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Multiplex IHC (mIHC) in Human, Mouse, Rat samples.
What is the molecular weight of Arx?
Anti-Arx [EPR27481-32] (ab308260) specifically detects a band for Arx (UniProt: Q96QS3) at a molecular weight of 58kDa.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR27481-32] also available for your convenience: ab308260, Carrier free -
ab308261
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Arx protein also known as Aristaless related homeobox is a transcription factor encoded by the ARX gene. Its molecular mass is approximately 55 kDa. Arx is mainly expressed in the brain and pancreas where it plays roles in development. The protein contains a homeobox domain which allows it to bind DNA and regulate transcription. In neurons Arx modulates the development and differentiation affecting various neuronal populations.
Biological function summary
Arx influences the development of the central nervous system and pancreatic functions. Arx operates as part of a regulatory network that includes other transcription factors. It coordinates with these factors to manage the expression of genes required for neuronal subtype specification. In the pancreas Arx impacts the fate determination of endocrine cells particularly influencing alpha-cell development over beta-cell development.
Pathways
Arx is an important player in both the neuronal differentiation and endocrine development pathways. It interacts with proteins like Pax4 and Nkx2.2 within these pathways ensuring proper cell-type specification and differentiation. These pathways ensure the formation of diverse neuronal subclasses and appropriate distribution of endocrine cells in the pancreas.
Arx is associated with epilepsy and intellectual disability. Mutations in the ARX gene can lead to X-linked intellectual disability and contribute to the development of epilepsy. In both conditions Arx's interaction with proteins such as DCX (Doublecortin) and LIS1 is significant as these proteins are implicated in neuronal migration and cortical development. Hence alterations in Arx function can disrupt these processes leading to neurological disorders.