Abcam, ab308403, Anti-SARS CoV 2 (COVID 19) ORF9b antibody [HL1918]

Size: 100µL
Rabbit Recombinant Monoclonal SARS CoV-2 ORF9b protein antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Transfected cell line - SARS-CoV-2 samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to SARS-CoV-2 9b.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1918,
Isotype:IgG,
Carrier free:Yes,
Reacts with:SARS-CoV-2,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to SARS-CoV-2 9b.P0DTD2

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS-CoV-2 ORF9b protein sometimes referred to as ORF9b protein is a small accessory protein with a mass of approximately 9 kDa. This protein is encoded by the open reading frame 9b (ORF9b) of the SARS-CoV-2 virus. It is expressed within the infected host cells where the virus replicates. ORF9b protein localizes to the mitochondria and plays a structural role in modulating host cellular processes during infection.
Biological function summary
The ORF9b protein interacts with the host immune system by inhibiting the type I interferon signaling pathway. This protein acts as a part of the viral evasion mechanisms allowing SARS-CoV-2 to escape host immune detection. ORF9b does not form part of a larger protein complex by itself but operates through interactions with host proteins affecting the host's antiviral responses.
Pathways
ORF9b disrupts the type I interferon immune signaling pathway one of the host's key antiviral defenses. It interacts with proteins such as Tom70 a mitochondrial import receptor. This interaction hampers the signaling cascade leading to reduced production of interferon which normally activates immune responses against viral infections. ORF9b's role in these pathways directly counteracts the host's ability to mount a timely defense against SARS-CoV-2 infection.
ORF9b is associated with the pathogenesis of COVID-19 the disease caused by SARS-CoV-2. Its ability to suppress immune signaling can contribute to the severity of COVID-19 by enabling viral persistence and exacerbating inflammatory responses. Additionally ORF9b interaction with ubiquitin system proteins such as MAVS facilitates immune evasion highlighting its role in the disease progression and severity.