Abcam, ab308520, Anti-Golgin 97 antibody [EPR27333-18]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal Golgin 97 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IP and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27333-18,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, Flow Cyt (Intra), ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Golgin-97 also known as Golgin subfamily A member 1 is a protein that plays a significant role in the Golgi apparatus function. This protein has a molecular mass of approximately 97 kDa. Golgin-97 is widely expressed in the Golgi apparatus of eukaryotic cells. Its structure facilitates its function as a membrane-bound protein influencing the organization of the Golgi stack and maintenance of the Golgi ribbon.
Biological function summary
Golgin-97 participates in tethering of transport vesicles to the Golgi membrane ensuring efficient trafficking of proteins to their correct destinations. It is part of the golgin family which includes several coiled-coil proteins critical for Golgi structure and dynamics. Golgin-97 acts within a larger protein complex that interacts with other Golgi-associated proteins to regulate vesicle docking and fusion.
Pathways
Protein and lipid trafficking involve Golgin-97 significantly as it aids in vesicular transport coordination from the endoplasmic reticulum to the Golgi and within the Golgi stacks. The protein interacts closely with Rab GTPases a class of proteins that regulate vesicle movement. Golgin-97's function intertwines with pathways like the secretory pathway and the endocytic pathway linking it to other proteins such as Rab6 and Rab9.
Golgin-97 has associations with pathologies involving Golgi dysfunction and transport defects. For instance it relates to diseases like neurodegenerative disorders where proper protein trafficking is disrupted. The malfunction of Golgin-97 can affect proteins like Alzheimer's disease proteins as vesicular transport failure can lead to their mislocalization or aggregation contributing to disease progression.