Abcam, ab308526, Anti-ALDH1A3 antibody [EPR27504-83]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ALDH1A3 antibody. Suitable for WB, ICC/IF, IP and reacts with Recombinant fragment - Human, Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27504-83,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ICC/IF, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH1A3 also known as Aldehyde Dehydrogenase 1 Family Member A3 is an enzyme with a molecular mass of approximately 55 kDa. It belongs to the aldehyde dehydrogenase family which is responsible for oxidizing aldehydes into carboxylic acids. ALDH1A3 plays an important role in the metabolism of retinaldehyde into retinoic acid an important biochemical reaction in the body. This enzyme shows high expression in tissues such as the liver kidney and neural tissue.
Biological function summary
The role of ALDH1A3 extends beyond simple metabolic processes. It is involved in the regulation of retinoid signaling influencing various cellular processes such as differentiation and proliferation. ALDH1A3 does not operate in isolation; it is often part of a complex interplay of enzymes that regulate local concentrations of retinoic acid which serves as a signaling molecule influencing gene expression. This regulatory capability underlines its importance in developmental and physiological patterns.
Pathways
ALDH1A3 is essential in the retinoic acid signaling pathway and the metabolic pathway of vitamin A derivatives. It interacts with other ALDH family members such as ALDH1A1 and ALDH1A2 in the synthesis and degradation of retinoic acid. Through these pathways ALDH1A3 also impacts the Wnt and Hedgehog pathways which are important for cellular growth and differentiation.
ALDH1A3 connects with several neurodegenerative and cancer conditions. Studies have indicated a correlation between ALDH1A3 expression and certain types of cancer including breast cancer and glioblastoma. In cancer aberrant ALDH1A3 levels can affect cancer stem cell properties and tumor progression. Additionally the protein interacts with other proteins like ALDH1L1 and ALDH3A1 which might also play roles in tumor metabolism and resistance to chemotherapy.