Abcam, ab308617, Anti-Synaptogyrin 1 antibody [EPR25081-18]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Synaptogyrin 1 antibody. Suitable for WB, IHC-P, IP, ICC/IF, Flow Cyt (Intra) and reacts with Recombinant fragment - Human, Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25081-18,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:Flow Cyt (Intra), IP, WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptogyrin 1 also known as SYG1 or Synaptogyrin-1 mechanically functions as an integral membrane protein involved in synaptic vesicle dynamics. It is a protein weighing approximately 29 kDa. Researchers have found SYG1 abundantly expressed within neural tissues particularly the presynaptic terminals of neurons. This protein shows involvement in the regulation of synaptic vesicle availability and neurotransmitter release implying its mechanical importance in synaptic function.
Biological function summary
Synaptogyrin 1 contributes to the modulation of synaptic vesicle cycling and neurotransmitter release. It participates in forming complexes that interact with other synaptic vesicle proteins likely supporting the organization and maintenance of synaptic vesicle pools. The presence of SYG1 in synaptic nerve terminals signifies its role in maintaining synaptic transmission efficiency and neuronal communication over synapses.
Pathways
Synaptogyrin 1 is linked to neurotransmission processes and synaptic vesicle recycling pathways. Researchers recognize its participation in the SNARE complex interplay important for vesicle fusion and neurotransmitter release. SYG1 associates with proteins like Synaptophysin and VAMP2 which all contribute to the maintenance of the synaptic vesicle life cycle ensuring proper communication between neurons.
Synaptogyrin 1 relates to neurological conditions such as schizophrenia and epilepsy. Misexpression or dysfunction of SYG1 disrupts synaptic signal transmission contributing to these disorders. Studies have shown it is associated with proteins such as NRG1 and DISC1 implicated in schizophrenia as well as alterations in glutamatergic pathways linked to epilepsy. Understanding its interaction and regulation could offer insights into therapeutic strategies for synaptic dysfunction-related diseases.