Abcam, ab309346, Anti-SPIB antibody [EPR26784-117]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SPIB antibody. Suitable for WB, IHC-P, ICC/IF, Flow Cyt (Intra), IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26784-117,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, Flow Cyt (Intra), WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SPIB protein also known as Spi-B transcription factor is a member of the ETS family of transcription factors. Its molecular weight is approximately 31 kDa. SPIB is expressed mainly in lymphoid tissues including the spleen thymus and lymph nodes with high activity observed in B-cells and plasmacytoid dendritic cells. As a transcription factor SPIB binds to specific DNA sequences and influences the transcription of various genes involved in immune response and cellular development.
Biological function summary
SPIB regulates gene expression important for immune system function. It plays a role in hematopoiesis particularly in the differentiation and function of B-cells and plasmacytoid dendritic cells. SPIB does not form complexes with other proteins in a classical sense but it does interact with other transcription factors within the cell’s nucleus to modulate gene expression. This regulation is significant for ensuring the immune system's proper response to pathogens.
Pathways
SPIB influences several critical biological pathways. It is an important player in the Toll-like receptor (TLR) signaling pathway which is essential for recognizing pathogens and activating innate immunity. Within this pathway SPIB interacts with proteins such as IRF4 and IRF8 which also play roles in immune system regulation. SPIB's involvement extends to the B-cell receptor signaling pathway influencing the development and function of B-cells.
SPIB has associations with certain autoimmune conditions and hematological malignancies. In particular alterations in SPIB expression are linked to systemic lupus erythematosus (SLE) an autoimmune disease characterized by the immune system attacking its own tissues. Furthermore SPIB can influence the pathogenesis of some lymphomas such as diffuse large B-cell lymphoma (DLBCL) in which IRF4 also plays a pivotal role. Understanding SPIB's involvement in these diseases provides potential targets for therapeutic intervention.