Abcam, ab309473, Anti-SCN3A antibody [EPR25135-66]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SCN3A antibody. Suitable for WB and reacts with Transfected cell lysate - Human, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25135-66,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCN3A also known as sodium channel voltage-gated type III alpha subunit or NaV1.3 plays a mechanical role in the conduction of electrical signals in excitable cells. It forms part of the voltage-gated sodium channels that are critical in the generation and propagation of action potentials. SCN3A has a molecular mass of approximately 260 kDa and is expressed broadly in the central nervous system particularly in neurons.
Biological function summary
The voltage-gated sodium channel SCN3A contributes to rapid depolarization in neuronal action potentials. It is an important component of a larger sodium channel complex which includes beta subunits that regulate the kinetic properties and localization of these channels. This enables proper neuronal signaling and communication affecting processes such as neurotransmission and response to stimuli.
Pathways
SCN3A influences the regulation of neuronal excitability and synaptic activity. It operates within the action potential pathway and has connections to the calcium signaling pathway which impacts numerous cellular processes. SCN3A functions alongside proteins such as SCN1A and SCN2A within these pathways contributing to the integrated organization of electrical signaling in neurons.
Mutations or dysregulations in SCN3A relate to epilepsy and neurodevelopmental disorders. SCN3A's interaction with SCN1A is significant as alterations in sodium channel function can lead to imbalance in neuronal excitability and seizures. These relationships highlight the importance of SCN3A in maintaining normal neural function and its potential as a therapeutic target in related neurologic conditions.