Abcam, ab309538, Anti-LMX1A antibody [EPR27269-57]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal LMX1A antibody. Suitable for WB, IHC-P and reacts with Recombinant fragment - Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27269-57,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMX1A also known as LIM homeobox transcription factor 1 alpha serves as a transcription factor involved in embryonic development. It belongs to the LIM homeobox gene family and weighs approximately 42 kDa. This protein primarily localizes in the central nervous system and developing limb tissues. It plays an important role in the differentiation and development of dopamine-producing neurons which are important for proper nervous system function.
Biological function summary
The presence of LMX1A is essential for the development of dopaminergic neurons in the midbrain. It functions as part of a complex transcriptional network with other key transcription factors such as NURR1 and PITX3 to regulate genes essential for dopamine synthesis and neuron maintenance. Through its actions LMX1A influences the dopaminergic system contributing to motor control and behavior regulation. This makes it important for studies in neurobiology and developmental biology.
Pathways
LMX1A is an integral component in the Wnt signaling pathway which is vital for maintaining dopaminergic neuron populations. It directly impacts the regulation and expression of genes related to dopamine synthesis. In collaboration with transcription factors like NURR1 LMX1A promotes the production of enzymes necessary for dopamine metabolism. This pathway plays an important role in neuronal survival and connectivity illustrating the connection of LMX1A to other proteins within this system.
Alterations in LMX1A expression or function are linked to Parkinson's disease and neural developmental disorders. In Parkinson's disease the degeneration of dopaminergic neurons occurs where LMX1A plays an important role in neuronal development and maintenance showcasing its potential therapeutic significance. Furthermore downregulation of LMX1A can lead to a disrupted neuronal development illustrating its impact on diseases associated with neurological development while the protein NURR1 is also critically involved in these processes.