Abcam, ab310660, Alexa Fluor® 594 Anti-NDUFAB1 antibody [EPR6725]

Size: 100µL
Rabbit Recombinant Monoclonal NDUFAB1 antibody - conjugated to Alexa Fluor® 594.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6725,
Isotype:IgG,
Conjugation:Alexa Fluor® 594,
Excitation/Emission:Ex: 590nm, Em: 617nm,
Carrier free:No,
Applications:Antibody Labelling, Target Binding AffinitySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFAB1 also known as mitochondrial acyl-carrier protein is a small protein with a mass of approximately 16 kDa. It plays a role in the mitochondrial fatty acid synthesis pathway and the assembly of the electron transport chain complexes. It is ubiquitously expressed in various tissues indicating a significant role in cellular metabolism. The protein anchors to the matrix side of the inner mitochondrial membrane where it performs its mechanical functions.
Biological function summary
NDUFAB1 is a component of the mitochondrial respiratory chain specifically part of complex I also known as NADH:ubiquinone oxidoreductase. The protein binds to acyl groups and facilitates their transfer within mitochondrial processes. This function is important for the maintenance and regulation of energy production in cells. Its involvement in the synthesis of lipoic acid an essential cofactor for several mitochondrial enzyme complexes further highlights its biological significance.
Pathways
The complex I of which NDUFAB1 is a part participates in the oxidative phosphorylation pathway. This pathway is major in adenosine triphosphate (ATP) production which is critical for energy metabolism. NDUFAB1 closely interacts with NADH and other subunits within the complex to relay electrons through the mitochondrial membrane. This interaction is related to other proteins such as NDUFS6 and NDUFS7 contextualizing NDUFAB1 within a network integral for cellular respiration.
Research shows that mutations or dysregulation of NDUFAB1 can be associated with mitochondrial diseases such as Leigh syndrome a severe neurological disorder. The dysfunction of complex I in these diseases affects energy production which impacts high-energy demanding tissues. NDUFS1 is another protein within complex I that when mutated can also lead to similar disorders indicating that both proteins play roles in the development of mitochondrial dysfunctions.