Abcam, ab31291, Anti-Renalase antibody

Size: 100µg
Goat Polyclonal Renalase antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human RNLS aa 200-250.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RNLS aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q5VYX0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Renalase also known as RNLS is a flavoprotein that catalyzes the oxidation of catecholamines such as dopamine and norepinephrine. It has a mass of approximately 37 kDa. The protein is expressed in the kidney heart and other tissues including the liver and brain. Its enzymatic activity helps in regulating blood pressure and cardiac function by metabolizing circulating monoamines.
Biological function summary
Renalase impacts the cardiovascular system through its enzymatic function that reduces systemic catecholamine levels. It has been shown the protein interacts with catecholamines beyond the boundaries of a simple enzymatic reaction. Renalase may form complexes with other enzymes that participate in detoxifying catecholamines. Researchers have studied its effects on catecholamine-related stress responses highlighting a potential modulatory function beyond simple substrate degradation.
Pathways
The metabolism of catecholamines involves Renalase in the regulation of the sympathetic nervous system and its associated pathways. Renalase fits into the catecholamine degradation pathway where it works alongside other enzymes such as monoamine oxidase which also breaks down neurotransmitters. These actions influence the broader systemic pathways associated with cardiovascular health by maintaining a balance in neurotransmitter levels and resultant blood pressure regulation.
Renalase has been associated with hypertension due to its role in catecholamine metabolism. Abnormal Renalase function can contribute to increased circulating catecholamines leading to elevated blood pressure. Additionally studies have suggested a link between Renalase and chronic kidney disease where alterations in Renalase activity may exacerbate kidney dysfunction. The relationship between Renalase and proteins like angiotensin-converting enzyme (ACE) further hints at its potential involvement in blood pressure regulation and renal pathology.