Abcam, ab313485, Anti-FOXN3 antibody [RP23040211]

Size: 100µg
Rabbit Recombinant Monoclonal FOXN3 antibody. Suitable for ICC/IF, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FOXN3.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:RP23040211,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOXN3.O00409

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXN3 also known as Forkhead Box N3 is a transcription factor that regulates transcription of target genes. The protein belongs to the family of forkhead box transcription factors and possesses a conserved DNA-binding domain. FOXN3 has an approximate molecular weight of 74 kDa. It is expressed in various tissues including the liver heart and kidneys. This protein contributes significantly to cellular stress responses and developmental processes.
Biological function summary
FOXN3 modulates gene expression related to cell cycle control and apoptosis. It acts within a complex to influence the stability and transcriptional activity of other proteins. As part of the MLL complex FOXN3 co-regulates gene expression essential for hematopoietic stem cell maintenance. Through controlling specific target genes it plays a critical role in development and differentiation impacting both normal physiological processes and pathological conditions.
Pathways
FOXN3 is involved in the regulation of the p53 pathway a critical pathway for tumor suppression and cell cycle control. The protein collaborates with p53 to manage stress-induced transcriptional responses. In the NF-kB signaling pathway FOXN3 regulates immune and inflammatory responses positioning itself as an important mediator of immune functions. It interplays with proteins like MLL and p21 emphasizing its significance in these pathways.
FOXN3 associates with cancer particularly breast cancer contributing to its development and progression through aberrant regulation of cell cycle genes. Dysregulation of FOXN3 links to developmental disorders impacting genes that are essential during embryogenesis. In cancer FOXN3 interacts with proteins like BRCA1 amplifying the effects of its dysfunction in tumorigenesis.