Abcam, ab313603, Human FCRL5 ELISA Kit

Size: 1 x 96Tests
Human FCRL5 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human FCRL5 in Human in Cell Culture Media, Biofluids samples.
Key facts
Detection method:Colorimetric,
Sample types:Cell culture supernatant, Plasma, Serum,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 1.64 ng/mL,
Range:1.64 - 400 ng/mL,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human FCRL5 (Fc Receptor-Like 5) ELISA kit is an
in vitro
enzyme-linked immunosorbent assay for the quantitative measurement of human FCRL5 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human FCRL5 coated on a 96-well plate.
This ELISA kit shows no cross-reactivity with the following cytokines tested: human Activin RIIA, Biglycan, CA13, CA2, CA72-4, CLEC-2, C-myc, Cystatin D, Erythropoietin, FGF-16, GATA-4, GFR alpha-1, GFR alpha-2, Granzyme B, Granzyme H, HIF1a, htPAPP-A, IFNb, IL-17RC, IL-19, IL 20R beta, IL-22, ILT-4, LAIR2, LSECtin, Netrin-4, Norrin, NRG1a, PD-L2, PDX-1, Podovalyxin, RGM-C, S100A1, Semaphorin 6A, SLITRK5, SR-AI, ST6GAL1, Thyroid Peroxidase, Troponin C.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FCRL5 also known as CD307 or Fc receptor-like 5 is a protein predominantly expressed on the surface of B cells and plasma cells. This protein weighs approximately 98 kDa. FCRL5 features structural similarities to classical Fc receptors suggesting a role in immune responses. Its expression is tightly regulated throughout B cell development and has been detected in lymphoid tissues with higher levels reported in bone marrow and secondary lymphoid organs.
Biological function summary
FCRL5 modulates the immune system by influencing B cell activation and differentiation. It participates in the formation of immune complexes playing a dual role in both promoting and inhibiting immune responses depending on the surrounding conditions. This regulatory function suggests that FCRL5 can adjust immune system activities to maintain homeostasis. It acts independently and might form complexes with other immune regulatory proteins to fine-tune B cell responses.
Pathways
FCRL5 plays a role in the adaptive immune response and is associated with the B cell receptor (BCR) signaling pathway. It interacts with proteins such as CD19 and CD79 influencing downstream signaling cascades critical for B cell maturation and effector functions. The interaction of FCRL5 with these pathways highlights its importance in modulating signal transduction that leads to cytokine production and antibody generation.
FCRL5 has been implicated in the pathogenesis of autoimmune diseases and certain hematological cancers such as chronic lymphocytic leukemia (CLL). Abnormal expression or mutations of FCRL5 can dysregulate normal B cell function contributing to disease development. In CLL FCRL5 potentially interacts with proteins like leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) influencing cancer cell survival and proliferation making it a target for therapeutic intervention and a potential biomarker for disease progression.