Abcam, ab313863, Anti-Elongin-C antibody [HL1683] - BSA and Azide free

Size: 100µL
Rabbit Recombinant Monoclonal Elongin-C antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human, Drosophila melanogaster, Cat, Dog, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human ELOC conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1683,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Drosophila melanogaster, Dog, Cat, Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELOC conjugated to Keyhole Limpet Haemocyanin.Q15369

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Elongin C also known as Elongin BC is a small protein with a mass of approximately 11 kDa. This protein is part of the Elongin complex which includes Elongin B and Elongin A. It is widely expressed in various tissues facilitating its role in transcriptional regulation. Elongin C works mechanically by forming a complex with Elongin B to elongate RNA polymerase II transcription and it acts as an adaptor in various cellular processes.
Biological function summary
Elongin C participates in stabilizing the association of Elongin A with RNA polymerase II. It is an essential component of the transcription elongation complex influencing the transcriptional activity of genes. By forming a complex with Elongin B it propels the transcription process forward particularly in response to signals that regulate transcription elongation. Elongin C also connects with the cullin-RING E3 ubiquitin ligase (CRL) complex contributing to protein degradation pathways.
Pathways
Elongin C plays a significant role in the ubiquitin-proteasome system which targets proteins for degradation. It functions alongside Elongin A and Elongin B in this pathway where these components coordinate to control protein levels in the cell. Elongin C associates with the VHL (Von Hippel-Lindau) tumor suppressor protein in the pathway responsible for hypoxia-inducible factor (HIF) degradation therefore influencing cellular responses to oxygen availability.
Alterations in Elongin C are implicated in cancer and von Hippel-Lindau disease. The disruption of its function can affect the stability and degradation of HIF leading to aberrant cellular proliferation and tumor progression. Elongin C through interaction with VHL highlights its importance in managing proper cell growth and differentiation underpinning its potential role in developing therapeutic targets for cancer treatment.