Abcam, ab314145, Anti-NTT4 antibody [EPR28520-77] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal S6A17 antibody. Carrier free. Suitable for IHC-P, WB, IP, IHC-Fr, ICC/IF, I-ELISA and reacts with Human, Mouse, Rat, Recombinant fragment samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28520-77,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, IHC-Fr, ICC/IF, IP, WB, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab314145 is the carrier-free version of
ab314144
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NTT4 also known as SLC6A17 is a sodium-dependent neurotransmitter transporter. This protein has a mass of approximately 70 kDa and is found primarily in the brain's cortical and hippocampal regions. It facilitates the uptake of neutral amino acids by neurons. The transport mechanism involves moving neurotransmitter molecules across cell membranes influencing synaptic communication.
Biological function summary
The function of NTT4 involves its role in the reuptake of amino acids critical for neurotransmission. As a member of the solute carrier family 6 (SLC6) NTT4 operates as part of a larger transporter complex system. It ensures that neurons maintain proper concentrations of neurotransmitters which are necessary for effective synaptic transmission and neuronal communication.
Pathways
NTT4 functions within the neurotransmitter transport and synaptic signaling pathways. It closely interacts with proteins such as glutamate and GABA transporters contributing to maintaining excitatory and inhibitory balance in the central nervous system. This balance is important for normal cognitive functions and prevents neurological dysregulation.
NTT4 is linked to neurological conditions like schizophrenia and epilepsy. A disruption in this transporter’s function can lead to imbalances in neurotransmitter levels which are implicated in these diseases. Related proteins like dopamine and serotonin transporters often show functional linkages with NTT4 in the pathological states of these psychiatric and neurological disorders.