Abcam, ab314385, Human S100P ELISA Kit

Size: 1 x 96Tests
Human S100P ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human S100P in Human in Biofluids, Cell Culture Media samples.
Key facts
Detection method:Colorimetric,
Sample types:Serum, Plasma, Cell culture supernatant,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 14 pg/mL,
Range:14 - 3500 pg/mL,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human S100P ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human S100P in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human S100P coated on a 96-well plate.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S100P also known as Protein S100-P is a member of the S100 family of proteins containing 94 amino acids with a mass of approximately 10 kDa. Its structure includes two EF-hand calcium-binding motifs which allow it to bind calcium ions effectively. You can find S100P in various tissues but it is highly expressed in the placenta prostate lungs and kidneys. These expression patterns suggest it has multiple roles in different cellular contexts.
Biological function summary
S100P plays a role in intracellular and extracellular calcium signaling. It influences cell survival proliferation and migration. It can function as a monomer but often interacts with other proteins forming complexes such as with RAGE (Receptor for Advanced Glycation End-products) which amplifies signaling cascades that control cellular responses. Its binding to calcium and interaction with RAGE modulate important cellular processes tied to cell cycle and cellular stress response.
Pathways
S100P is closely involved in the MAPK (Mitogen-Activated Protein Kinases) and RAGE signaling pathways. Its interaction with RAGE leads to activation of the MAPK pathway facilitating cellular responses such as growth and survival. S100P also coordinates with other S100 proteins such as S100A4 and S100A9 enhancing its involvement in regulating cellular functions through these pathways. These interactions highlight the importance of S100P in cellular communication and response mechanisms.
S100P is associated with various cancers like pancreatic and breast cancer. Its expression level often increases in malignancies where it promotes metastasis and poor prognosis. Through the RAGE pathway S100P influences tumor progression by altering cellular adhesion migration and immune response. In cancer biology it links with proteins such as E-cadherin and matrix metalloproteinases which further contribute to tumor invasiveness and metastasis making it a potential target for therapeutic intervention.