Abcam, ab314763, Anti-TMEM41B antibody [EPR28149-41]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TM41B antibody. Suitable for WB, IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28149-41,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM41B also known as Transmembrane Protein 41B is part of the ER membrane protein complex that plays a fundamental role in various cellular processes. It is a 35 kDa protein located predominantly in the endoplasmic reticulum membrane. TMEM41B shows expression in many tissues including heart brain kidney and skeletal muscle suggesting its important role across different biological systems.
Biological function summary
This protein functions in autophagy a process essential for cellular homeostasis and survival during stress conditions. TMEM41B associates with the ER-phagy complex where it is important for the regulation and expansion of autophagosomes. It works in coordination with proteins like VMP1 and ATG9A supporting the recruitment and stability of autophagosomal membranes which impacts the cell's ability to recycle and reuse cellular components.
Pathways
TMEM41B has a significant involvement in the autophagy and lipid metabolism pathways. It interacts with other proteins such as VMP1 and ATG9A mediating the lipid mobilization necessary for efficient autophagosome formation. These interactions ensure that TMEM41B plays a role in the homeostatic regulation of lipids and proteins contributing to proper cellular function and response to metabolic demands.
TMEM41B associates with conditions like neurodegeneration and certain viral infections. Alterations or deficiencies in TMEM41B can impact its autophagic function potentially leading to neurodegenerative diseases where protein aggregates accumulate as seen in relation to ATG9A dysfunction. Additionally studies link TMEM41B to the flavivirus life cycle suggesting its necessity in viral replication processes. These connections highlight its potential as a therapeutic target in disease management.