Abcam, ab314833, Human CFHR1 ELISA Kit

Size: 1 x 96Tests
Human CFHR1 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human CFHR1 in Human in Biofluids, Cell Culture Media samples.
Key facts
Detection method:Colorimetric,
Sample types:Serum, Plasma, Cell culture supernatant,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 0.14 ng/mL,
Range:0.14 - 100 ng/mL,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human CFHR1 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CFHR1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human CFHR1 coated on a 96well plate.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CFHR1 also known as Complement Factor H-Related protein 1 plays a role in the regulation of the complement system. This protein has a molecular mass of approximately 37 kDa. CFHR1 is mainly expressed in the liver and is present in plasma. The protein has structural similarities to Factor H with homologous domains known as short consensus repeats which contribute to its function in modulating complement activity.
Biological function summary
CFHR1 regulates the alternative pathway of the complement system. It can bind to complement component C3b inhibiting its activity and preventing over-activation of the complement cascade. CFHR1 does not function alone; it interacts with other proteins in the complement system although it forms no stable complex. Through these interactions CFHR1 maintains homeostasis in immune responses.
Pathways
CFHR1 participates significantly in the alternative complement pathway. It works alongside other complement factors such as Factor H to ensure balanced complement activation and regulation. CFHR1 indirectly influences the inflammatory response by regulating this pathway linking innate immunity processes with complement-mediated functions.
CFHR1 is linked to atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). In aHUS CFHR1 gene deletions can lead to unrestrained complement activation due to lack of regulation which involves Factor H. Similarly in AMD altered CFHR1 expression can affect complement regulation in the retinal tissue involving interactions with C3b and Factor H.