Abcam, ab314860, Anti-WDR41 antibody [EPR26180-218]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal WDR41 antibody. Suitable for WB, IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26180-218,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR41 also known as WD repeat domain 41 is a protein that participates in cellular processes through its distinctive structural motif. The protein has multiple WD40 repeats and shows a molecular mass of approximately 74 kDa. WDR41 is found within the cytoplasm and also shows expression in various tissues across the human body including the brain and kidney. This wide expression implies its involvement in essential cellular activities.
Biological function summary
WDR41 contributes to lysosomal function and acts as a component of the PI3P-binding WIPI3-WDR41 complex. The complex plays an important role in autophagy by promoting the formation of autophagosomes which are important for degrading and recycling cellular components. Additionally WDR41 participates in regulation of cellular homeostasis playing a role in maintaining the balance of proteins and organelles within the cell environment.
Pathways
WDR41 plays a significant role in the autophagy and mTOR signaling pathways. These pathways are key in regulating cell growth proliferation and survival. Autophagy involves several proteins and complexes with mTORC1 being a vital regulator that signals the inhibition or promotion of this catabolic process. WDR41 interacts with other proteins such as LC3 and FYCO1 which help to mediate the autophagic response within cells and provide insights into its integration in these critical pathways.
Improper functioning of WDR41 links to neurodegenerative diseases and metabolic syndromes. Disruption in its expression may contribute to the development of conditions such as Parkinson’s disease where misregulation of autophagy leads to the accumulation of damaged organelles and proteins. Additionally WDR41 connections with the mTOR pathway can influence type 2 diabetes progression. Its interactions with proteins like ULK1 and Atg13 emphasize its role in these disease contexts highlighting its potential as a target for therapeutic interventions.