Abcam, ab314889, Anti-1N Tau antibody [EPR25206-82]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TAU antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Transfected cell line - Human, Rat, Transfected cell lysate - Human, Recombinant fragment - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25206-82,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
1N Tau also known as human Tau protein plays a role in stabilizing microtubules in neurons. It is a low molecular weight protein with a mass of around 45 kDa. The expression of 1N Tau occurs mostly in the central nervous system but is also present in smaller quantities in peripheral nervous tissues. This protein binds directly to microtubules through its repeat domains which forms a tight and stable structure necessary for proper neuronal function.
Biological function summary
1N Tau is critical in the assembly and stabilization of the neuronal cytoskeleton. It normally functions as part of a larger microtubule-associated protein complex. By promoting microtubule polymerization it helps maintain the axonal transport system necessary for neuronal communication. The functional activity of 1N Tau can be controlled by phosphorylation a process that can modulate its binding affinity to microtubules.
Pathways
The cellular processes involving 1N Tau often intersect with important signaling cascades such as the MAPK/ERK and PI3K/Akt pathways. The alterations in phosphorylation states regulate its interaction with other microtubule-associated proteins like MAP2 and MAP4. This regulation ensures the stability of the neuronal cytoskeleton and influences processes like cell growth and survival impacting overall neuronal health and function.
Abnormal 1N Tau phosphorylation and aggregation are closely associated with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. These conditions often show the presence of paired helical filaments formed by hyperphosphorylated 1N Tau. Interaction with amyloid precursor protein (APP) in Alzheimer's disease suggests a link between Tau aggregation and amyloid beta pathology which contributes to neuronal dysfunction and cognitive decline.