Abcam, ab315380, Anti-5HT6 Receptor antibody [EPR26400-50]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal 5HT6 Receptor antibody. Suitable for mIHC, IHC-P, IHC-Fr and reacts with Rat, Mouse, Transfected cell line - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26400-50,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-Fr, mIHC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 5HT6 receptor also known as 5-hydroxytryptamine receptor 6 is a protein with a molecular mass of approximately 45 kDa. It is a G protein-coupled receptor (GPCR) that primarily binds serotonin and is expressed in the brain mainly in regions like the striatum olfactory tubercle and hippocampus. The receptor's mechanical role involves modulating neurotransmitter release and neuronal excitability which influences cognitive processes such as learning and memory.
Biological function summary
The 5HT6 receptor plays an integral role in modulating serotonergic transmission in the central nervous system. While it does not form a complex with other proteins its activity influences several neurotransmitter systems including dopamine and glutamate. By regulating these systems the receptor supports cognitive functions and affects mood regulation highlighting its significance in neuropsychological processes.
Pathways
The 5HT6 receptor holds a role in the serotonergic neurotransmission pathway and the receptor-mediated phosphoinositide pathway. It interacts with key proteins such as the adenylyl cyclase influencing cAMP accumulation and downstream signaling processes that impact synaptic plasticity and neurodevelopment. Its interaction with other receptors such as dopamine D2 receptors further defines its involvement in complex neuromodulatory networks.
The 5HT6 receptor links to neurological and psychiatric conditions like Alzheimer's disease and schizophrenia. Dysregulation of 5HT6 activity is associated with cognitive deficits and an altered mood where it also interacts with amyloid precursor protein (APP) and histamine H3 receptors respectively. Therapeutics targeting 5HT6 are under investigation for their potential to alleviate symptoms or modify disease progression in these disorders.