Abcam, ab315386, Anti-beta Sarcoglycan antibody [EPR28175-77]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal beta Sarcoglycan antibody. Suitable for WB, IHC-P, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28175-77,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Sarcoglycan is a glycoprotein that has different names including 35DAG or A3b. It plays an important role in muscle cells by integrating into the sarcoglycan complex. This protein has an approximate mass of 43 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Beta Sarcoglycan provides structural support to the muscle cell membrane by linking inside the dystrophin-associated glycoprotein complex (DGC).
Biological function summary
Beta Sarcoglycan acts to maintain the stability of the muscle cell's sarcolemma. It forms part of the sarcoglycan complex which is one component of a larger dystrophin-glycoprotein complex. This complex protects muscle fibers from the stress of contraction. By ensuring the integrity of the muscle membrane Beta Sarcoglycan contributes to muscle fiber repair and regeneration reducing the risk of damage from repetitive use.
Pathways
Beta Sarcoglycan belongs to the dystrophin-associated glycoprotein complex playing a role in the linkage between the cytoskeleton and extracellular matrix. This involvement occurs primarily in the DGC signaling pathway. The interaction with dystrophin and other sarcoglycans ensures effective signal transduction and mechanical stability during muscle contraction. It relates to proteins including dystrophin itself and other sarcoglycans like alpha and gamma that cooperate in the same pathway.
Beta Sarcoglycan connects closely to limb-girdle muscular dystrophy (LGMD). Mutations in the gene encoding this protein lead to muscle weakness and degeneration characteristic of LGMD. It has a direct relationship with other sarcoglycans like gamma and alpha as defects in these proteins can cause similar dystrophic conditions. The impaired function of Beta Sarcoglycan results in the breakdown of muscle membrane integrity contributing to the progression of the disease.