Abcam, ab315798, Anti-PMS1 antibody [EPR27158-78]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal PMS1 antibody. Suitable for WB and reacts with Human, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27158-78,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PMS1 also known as postmeiotic segregation increased 1 is a DNA mismatch repair protein with a molecular mass of approximately 96 kDa. This protein is widely expressed in various tissues highlighting its broad role in cellular function. PMS1 plays a mechanical role by participating in the process of detecting and repairing mismatches that occur during DNA replication. Its proper function ensures genomic stability and prevents errors that could potentially lead to cellular malfunctions.
Biological function summary
PMS1 is part of the mismatch repair (MMR) complex which includes other key proteins such as MLH1 and PMS2. This complex serves a critical role in maintaining DNA integrity by correcting base-pair mismatches. PMS1 collaborates with these proteins to ensure that DNA replication proceeds with high fidelity thereby safeguarding genetic information. By preventing accumulation of mutations PMS1 helps in maintaining cellular health and function.
Pathways
PMS1 integrates into the DNA damage repair pathway working closely with the homologous recombination repair mechanism. It interacts with other MMR proteins such as MLH1 to facilitate the repair process. This pathway is essential for cell cycle regulation and prevention of mutagenesis. MMR ensures that cells can respond effectively to DNA damage reducing the likelihood of carcinogenesis.
PMS1 is associated with Lynch syndrome which is a hereditary condition that increases cancer risk particularly colorectal cancer. The relationship between PMS1 and MLH1 is significant in this context as mutations in these genes can lead to dysfunctional DNA repair pathways. Consequently impaired PMS1 function may contribute to the accumulation of DNA errors promoting cancer development. The involvement of PMS1 in Lynch syndrome highlights the importance of its role in maintaining genomic stability and the potential impact of its dysfunction in hereditary cancers.