Abcam, ab316002, Anti-AP4B1 antibody [EPR28048-85]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal AP4B1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28048-85,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AP4B1 also known as Adaptor-Related Protein Complex 4 Beta 1 Subunit plays a critical role in the cellular transport mechanism. It is a component of the AP-4 adaptor complex which is involved in the sorting of cargo proteins at the trans-Golgi network. The protein has a mass of approximately 82 kDa. AP4B1 is primarily expressed in the brain and other tissues indicating its essential role in neuronal function and development.
Biological function summary
AP4B1 contributes to the function of the adaptor protein complex 4 (AP-4). This complex is important for recognizing and binding to sorting signals within the cytoplasmic tails of membrane proteins. AP4B1 facilitates the proper trafficking of proteins to endosomes and lysosomes impacting cellular homeostasis and function. Failure in such trafficking processes often leads to cellular malfunction.
Pathways
The AP4B1 protein is integral to pathways involving vesicular transport and protein sorting. It interacts with other adaptor-related proteins like AP4M1 within the AP-4 complex influencing the export of proteins from the Golgi apparatus. Additionally AP4B1 affects the lysosomal delivery of proteins playing a role in clathrin-independent pathways essential for maintaining cellular stability.
AP4B1 mutations are associated with neurologic conditions such as spastic paraplegia type 47 (SPG47). These mutations lead to improper sorting and trafficking of proteins contributing to neurodegeneration. Furthermore AP4B1 interactions with other proteins in the AP-4 complex like AP4E1 can exacerbate these conditions highlighting the importance of the complex in maintaining neurological health.