Abcam, ab316161, Anti-FAM134B antibody [EPR28817-67]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal RETR1 antibody. Suitable for WB, IP and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28817-67,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein FAM134B also known as JK-1 is an autophagy regulator with a molecular mass of approximately 50 kDa. FAM134B plays a critical role in the degradation of endoplasmic reticulum (ER) membranes. This protein expresses robustly in the neural tissues gastrointestinal tract and reproductive organs. FAM134B functions by binding to membranes and facilitating the removal of damaged ER components which maintains cellular homeostasis.
Biological function summary
FAM134B serves as an important player in maintaining cell health by its involvement in ER-phagy a selective autophagy process. It forms part of the ER-phagy complex and works alongside LC3 proteins to ensure efficient turnover of the ER membrane. Its activity helps prevent ER stress and safeguard cell survival under stress conditions. Failure in this pathway can lead to accumulation of misfolded proteins and impaired cell function.
Pathways
FAM134B interacts in the process of ER-associated degradation (ERAD) and autophagy-related pathways. It participates importantly in the calcium signaling pathway where FAM134B affects the homeostasis of calcium levels in the cytoplasm and ER. This interaction involves key signaling proteins such as ATG8 and ER-phagy receptors showing its essential role in cellular adaptation to stress.
FAM134B has significant associations with sensory neuropathy and colorectal cancer. In sensory neuropathy mutations or dysfunctions in FAM134B lead to the loss of pain perception due to improper ER turnover in neurons. It also links to colorectal cancer often showing altered expression that affects tumor progression. FAM134B interacts with proteins like p53 in cancer pathways which influences cell cycle regulation and apoptosis in cancerous cells.