Abcam, ab316858, Anti-SAP102 antibody [EPR28704-52]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SAP102 antibody. Suitable for Dot, WB, IHC-P, IHC-Fr, ICC/IF, Flow Cyt (Intra) and reacts with Recombinant fragment - Mouse, Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28704-52,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ICC/IF, Dot, Flow Cyt (Intra), IHC-P, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for human IHC, human ICC and human FC.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAP102 also known as DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) protein family. This protein weighs approximately 97 kDa and is mainly expressed in the brain. SAP102 plays a significant role in signal transduction by organizing synaptic signaling complexes. It contains PDZ domains that facilitate protein-protein interactions and its expression in neuronal synapses is notable.
Biological function summary
The interaction between SAP102 and N-methyl-D-aspartate (NMDA) receptors has major implications in synapse development and plasticity. SAP102 forms part of the postsynaptic density (PSD) complex which contributes to synaptic organization and dynamics. This complex is essential for the correct functioning of synaptic signaling pathways influencing learning and memory processes.
Pathways
The regulation of synaptic plasticity and neurotransmitter release involves SAP102. In this context it plays a part in the NMDA receptor signaling pathway and the synaptic vesicle cycle. SAP102 is associated with proteins such as PSD95 and SAP97 which work together to modulate synaptic strength and communication.
Abnormalities in SAP102 function or expression have links to neurodevelopmental disorders like intellectual disability and autism spectrum disorder. Mutations in SAP102 and related proteins such as neuroligins or neurexins can disrupt synaptic communication leading to defective neural circuit formation. Understanding SAP102's role in these disorders offers insights into potential therapeutic approaches.