Abcam, ab317104, Anti-Respiratory Syncytial virus type B G protein antibody [HL1733]

Size: 100µL
Rabbit Monoclonal antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Transfected cell lysate - Respiratory syncytial virus, Transfected cell line - Respiratory syncytial virus samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1733,
Isotype:IgG,
Carrier free:No,
Reacts with:Respiratory syncytial virus,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Respiratory Syncytial Virus (RSV) type B G protein also known as the glycoprotein B is a critical component of the RSV envelope. The mass of this protein is approximately 90 kDa. This protein plays a mechanical role by facilitating the attachment of the virus to the host cell surface which is an essential step for viral entry and infection. The G protein expresses on the surface of the RSV particles and helps the virus navigate the host environment thereby enhancing its ability to infect respiratory epithelial cells.
Biological function summary
The RSV type B G protein functions in immune evasion by modulating the host's immune response. It is not part of a larger multiprotein complex but interacts with components of the host immune system to subvert normal immune activities. For example it can interfere with host cell signaling pathways that would typically lead to a robust immune response allowing the virus to persist and propagate within the host tissues.
Pathways
RSV type B G protein actively participates in the infection process by engaging key cellular pathways like the integrin signaling pathway. The G protein interacts with proteins on the host cell surface such as heparan sulfate proteoglycans and CX3C chemokine receptor 1 (CX3CR1) aiding viral attachment and entry. These interactions facilitate subsequent downstream signaling that promotes viral penetration and replication within the host cells.
RSV type B G protein associates closely with conditions like bronchiolitis and pneumonia especially in infants and young children. Its role in immune modulation directly links to how these diseases manifest and progress. Additionally other viral proteins like the F protein contribute to similar pathologies through synergistic actions with the G protein worsening respiratory conditions and increasing the severity of respiratory tract infections.