Abcam, ab317161, Anti-ULK2 antibody [HL2206]

Size: 100µL
Rabbit Monoclonal ULK2 antibody. Suitable for ICC/IF, WB and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human ULK2.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2206,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ULK2.Q8IYT8

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ULK2 also known as UNC-51-like kinase 2 is a serine/threonine-protein kinase positioned within cellular processes. With an approximate molecular mass of 124 kDa ULK2 is expressed in various tissues prominently within the brain heart and skeletal muscle. This protein exhibits kinase activity essential for transferring phosphate groups to specific substrates affecting their function and activity.
Biological function summary
ULK2 functions as an important regulator in cellular autophagy the process that removes unnecessary or damaged cellular components. It acts as part of the ULK complex which includes ATG13 FIP200 and ATG101. This complex initiates the autophagy process by responding to nutrient availability and energy status within the cell effectively managing cellular homeostasis and survival.
Pathways
ULK2 is mainly involved in the autophagy pathway and the mTOR signaling pathway. The mTOR pathway influences cell growth and metabolism in response to nutritional signals hence ULK2 interacts with mTORC1 to relay signals important for appropriate autophagy initiation. Additionally ULK2 shares a functional relationship with AMPK which senses cellular energy levels and modulates autophagy in part through ULK2 activation.
ULK2 is associated with neurodegenerative diseases like Alzheimer's disease and can play a role in the pathology of certain cancers. Aberrant ULK2 activity alters autophagic processes contributing to the accumulation of misfolded proteins and impaired cell survival. The protein interacts with p62/SQSTM1 a known player in neurodegenerative disease pathways underlining its relevance to disease mechanisms.