Abcam, ab317388, Anti-Hsp90 alpha + Hsp90 beta antibody [S08-8A1]

Size: 100µL
Rabbit Monoclonal HS90A antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human HSP90AB1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:S08-8A1,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HSP90AB1.P08238

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hsp90 beta and Hsp90 alpha also known as Heat Shock Protein 90 are molecular chaperones involved in protein folding stabilization and degradation. Hsp90 beta and Hsp90 alpha have molecular masses of approximately 83 kDa. They are predominantly found in the cytosol but can be present in the nucleus and other cellular compartments. Hsp90 proteins are expressed ubiquitously in most cells reflecting their need in fundamental cellular processes.
Biological function summary
Heat Shock Proteins play an important role in maintaining cellular protein homeostasis. They participate as part of larger protein complexes that assist in the folding of nascent polypeptides and the refolding of denatured proteins. Hsp90 proteins regulate numerous client proteins including kinases and transcription factors which are essential for cell signaling and survival under stress conditions. These chaperones also protect cells from apoptosis by stabilizing involved client proteins.
Pathways
Heat Shock Proteins integrate into significant cellular pathways like the PI3K/AKT signaling and the MAPK/ERK pathway. Hsp90 supports the activity of various proteins involved in these pathways such as AKT kinase in the PI3K/AKT pathway and RAF kinase in the MAPK/ERK pathway. These pathways contribute to cell proliferation survival and metabolism with Hsp90 acting as an enabler for client protein fucntion.
Heat Shock Proteins are implicated in cancer and neurodegenerative diseases. Many tumors overexpress Hsp90 which stabilizes mutated proteins that drive cancer progression. This makes Hsp90 a potential target for anti-cancer therapies. In neurodegenerative disorders like Alzheimer's disease Hsp90 interacts with proteins such as tau influencing their aggregation state. Modulating this interaction may offer therapeutic avenues to alleviate symptoms associated with protein aggregation.