Abcam, ab317402, Anti-Staufen/STAU1 antibody [S03-3G2]

Size: 100µL
Rabbit Monoclonal Staufen/STAU1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Synthetic Peptide within Human STAU1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:S03-3G2,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human STAU1.O95793

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Staufen1 (STAU1) also known as Staufen double-stranded RNA binding protein 1 is an RNA-binding protein that plays a significant role in the regulation of mRNA localization stability and translation. It has a mass of approximately 58 kDa and is expressed in a variety of tissues including the brain testis and heart. STAU1 is known for binding to specific secondary structures in mRNA which influences the post-transcriptional gene regulation processes essential for cell function.
Biological function summary
Staufen1 participates in mRNA transport and localization within cells especially neurons. It forms part of a ribonucleoprotein complex which is involved in the movement of mRNA to distinct subcellular sites facilitating localized protein synthesis. This function is critical for the development and maintenance of cellular structures especially in cells with polarized functions such as neurons where precise protein localization is necessary for synaptic function and plasticity.
Pathways
Staufen1 is essential in processes related to mRNA decay and translation regulation. It is actively involved in the nonsense-mediated mRNA decay pathway ensuring the quality control of mRNA transcripts and preventing the synthesis of defective proteins. Additionally STAU1 interacts with proteins such as UPF1 an important player in this mRNA surveillance mechanism highlighting its role in ensuring accurate protein translation and cellular health.
Abnormalities in STAU1 function have been associated with neurodegenerative diseases and muscular disorders. Its interaction with proteins like SMN responsible for motor neuron maintenance links STAU1 to spinal muscular atrophy. Similarly STAU1's role in the regulation of mRNA at synapses connects it to neuronal disorders including some forms of intellectual disability where local protein synthesis at synapses is disrupted.