Abcam, ab317624, Anti-GPR37L1 antibody [EPR29125-35]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal G37L1 antibody. Suitable for IHC-P, IHC-Fr and reacts with Transfected cell line - Mouse, Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29125-35,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR37L1 also known as Prosaposin receptor GPR37L1 is an orphan G protein-coupled receptor with a mass of approximately 70 kDa. It is highly expressed in the central nervous system particularly in astrocytes and also in some peripheral tissues. The receptor is involved in signaling mechanisms through coupling with G proteins often leading to intracellular responses such as calcium mobilization or changes in cyclic AMP levels. Its expression pattern suggests a significant role in neural functions.
Biological function summary
GPR37L1 participates in modulating astrocytic activities which are critical for maintaining neural homeostasis. Although it does not typically form part of large protein complexes it interacts with various intracellular signaling components to exert its effects. Researchers have suggested that GPR37L1 could influence neuroinflammatory processes and cell survival due to its presence in neural tissues where it might regulate responses to stress and environmental cues.
Pathways
GPR37L1 plays a role in the Wnt signaling pathway and the MAPK signaling pathway both of which are essential for cellular growth differentiation and survival. These pathways involve interactions with other proteins like Frizzled receptors in the Wnt pathway and Ras proteins in the MAPK pathway. GPR37L1's contribution to these pathways highlights its importance in cellular communication and signal transduction potentially coordinating responses to different physiological and pathological stimuli.
GPR37L1 has been associated with neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. This receptor's altered signaling might contribute to the pathophysiology of these disorders linking to proteins like alpha-synuclein and amyloid precursor protein respectively. Understanding the role of GPR37L1 in these diseases could offer new insights for therapeutic strategies aimed at modulating its activity to improve neuronal health and function.