Abcam, ab318974, Anti-IFRD1 antibody [EPR28794-89]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal IFRD1 antibody. Suitable for Dot, WB, Flow Cyt (Intra) and reacts with Recombinant fragment - Human, Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28794-89,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:Dot, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon-related developmental regulator 1 (IFRD1) also known as PC4 is involved in transcription regulation and cellular differentiation. It is a nuclear protein with a mass of approximately 48 kDa. IFRD1 is expressed in various tissue types including muscle lung and the immune system among others. As a transcriptional co-regulator it modulates the activity of several transcription factors through interactions with other proteins affecting gene expression patterns.
Biological function summary
IFRD1 regulates immune response and cellular differentiation processes. It functions as part of the transcriptional regulation complex influencing genes involved in tissue regeneration and repair. In the immune system IFRD1 modulates macrophage activation and influences neutrophil survival. The involvement in these biological processes indicates its important role in both normal physiological functions and response to injury or inflammation.
Pathways
IFRD1 significantly contributes to the NF-kB signaling and JAK/STAT pathways. In these pathways it interacts with key regulatory proteins to influence transcriptional outcomes. The NF-kB pathway for instance involves interactions with transcription factors that control inflammation and immune responses. Meanwhile the JAK/STAT pathway important for cytokine signaling sees IFRD1 engaging with STAT proteins. Through these pathways IFRD1 plays a role in regulating cellular responses to external stimuli.
IFRD1 associates with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Research links IFRD1 with modulation of inflammation where improper regulation can exacerbate respiratory conditions as observed in CF. In COPD impaired IFRD1 function may lead to increased inflammation and deteriorated lung function. Relationships with other proteins such as the CFTR gene product in cystic fibrosis highlight IFRD1's potential role in the pathophysiology of these diseases offering insights into possible therapeutic interventions.