Abcam, ab319101, Anti-BTN3A1 + BTN3A2 + BTN3A3 antibody [EPR28070-58]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal BTN3A1 antibody. Suitable for Dot, Flow Cyt, ICC/IF and reacts with Recombinant fragment - Human, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28070-58,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, ICC/IF, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The BTN3A proteins also known as CD277 consist of three members: BTN3A1 BTN3A2 and BTN3A3 which typically weigh approximately 57 kDa. These proteins are expressed on surface of various immune cells including T cells B cells and natural killer (NK) cells. Btn3A2 and Btn3A3 augment Btn3A1's function in immune regulation through heteromeric complex formation. BTN3A proteins belong to the B7 family involved in modulation of immune responses.
Biological function summary
BTN3A proteins influence activation and proliferation of gamma delta T cells which are critical for immune surveillance against pathogens and tumors. BTN3A1 BTN3A2 and BTN3A3 together form complexes essential for this function. By facilitating recognition of phosphoantigens these proteins modulate immune activation impacting T cell responses. BTN3A proteins serve as important players in immune regulation enabling cells to recognize and respond effectively to tumors and infections.
Pathways
BTN3A proteins participate in the modulation of the immune checkpoint pathway impacting T cell receptor signaling and the immune-suppressive tumor microenvironment. They interact with proteins like Perforin 1 which play important roles in immune responses. These interactions not only regulate immune activation but also influence tumor immune evasion processes making BTN3A proteins significant in cancer immunotherapy research.
BTN3A proteins relate to cancer and autoimmune conditions such as lupus erythematosus. Changes in BTN3A expression or function can lead to abnormal immune responses contributing to disease progression. BTN3A proteins' interaction with other immune checkpoint proteins like PD-1 and CTLA-4 influences cancer progression and autoimmune disease pathogenesis through altered immune cell activation and tolerance. Understanding these relationships helps in developing therapies targeting immune checkpoints for better disease management.