Abcam, ab32097, Anti-beta Arrestin 1 (phospho S412) antibody [E109]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal beta Arrestin 1 phospho S412 antibody. Suitable for Dot, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:E109,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Arrestin 1 also known as β-arrestin b-arrestin or ARRB1 is a protein that plays an important role in cell signaling mechanisms. It has a molecular mass of approximately 47 kDa and is expressed in various tissues with high expression levels in the brain and testes. Beta Arrestin 1 binds to G protein-coupled receptors (GPCRs) leading to the termination of coupling between the GPCRs and G proteins. This function is essential in regulating the receptor's signal and mediating receptor desensitization.
Biological function summary
Beta Arrestin 1 functions beyond GPCR desensitization by participating in receptor internalization and the initiation of alternative signaling pathways known as arrestin-mediated signaling. It acts as part of a greater complex with clathrin and adaptin which facilitates the endocytosis of GPCRs. In doing so beta Arrestin 1 can modulate different signaling pathways independently of G proteins influencing various cellular responses.
Pathways
Beta Arrestin 1 integrates into the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are important for regulating diverse cellular processes including proliferation differentiation and survival. Through the MAPK/ERK pathway beta Arrestin 1 is connected to proteins such as extracellular signal-regulated kinases (ERK1/2). In the context of the PI3K/AKT pathway it associates with phosphoinositide 3-kinase helping to control cell growth and survival mechanisms.
Disruptions involving beta Arrestin 1 have implications in cancer and cardiovascular diseases. In cancer abnormal beta Arrestin 1 activity can influence tumor growth by altering cell proliferation and survival signaling pathways. It links to proteins like ERK1/2 and PI3K which can drive oncogenic processes. In cardiovascular disorders beta Arrestin 1 is implicated in heart failure where its altered activity affects cardiovascular signaling pathways influencing heart function and response to stress.