Abcam, ab32133, Anti-Rsk 2 / MAPKAP Kinase 1b antibody [Y83]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Rsk 2 / MAPKAP Kinase 1b antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:Y83,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The antibody recognises Rsk2. It does not cross react with other S6 kinase family members.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rsk 2 also known as MAPKAP Kinase 1b is a 60- to 90-kilodalton serine/threonine kinase belonging to the RSK family. It plays an important role in cell signaling by phosphorylating various substrates. The protein is expressed in many tissues including the brain heart and liver. Rsk 2 contains two distinct catalytic domains which allow it to carry out its functions efficiently. Activation of this protein involves its interaction with ERK/MAPK signaling proteins.
Biological function summary
Rsk 2 is a central player in the regulation of cell growth survival and motility. It exists as part of the larger MAPK/ERK pathway where it acts downstream of ERK1/2. Upon activation Rsk 2 phosphorylates target proteins which regulate gene expression cell cycle progression and apoptosis. This allows it to control multiple aspects of cell physiology contributing to proper cellular responses to external stimuli.
Pathways
The protein Rsk 2 integrates into the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are essential for controlling processes such as proliferation and differentiation. Rsk 2 activation depends on upstream kinases like MEK and ERK. In the MAPK/ERK pathway it collaborates with other kinases and transcription factors to mediate cellular responses. This involvement places Rsk 2 at a nexus of signaling events that finely tune cell function and fate.
Rsk 2 mutations can lead to Coffin-Lowry syndrome which is a form of intellectual disability accompanied by physical abnormalities. The protein has also been implicated in certain cancer types whereby its upregulation supports tumor growth and survival. In these contexts interactions between Rsk 2 and proteins such as ERK and AKT contribute to the pathological alterations that occur in these diseases. The ongoing study of Rsk 2 holds potential for understanding and targeting conditions where it plays a role.