Abcam, ab321994, Anti-GSH2 antibody [EPR29122-65]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GSX2 antibody. Suitable for Dot, IHC-Fr, IHC-P, WB and reacts with Transfected cell lysate - Mouse, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29122-65,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-Fr, IHC-P, Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Not working in mouse cell lines

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSH2 also known as glutathione synthetase 2 adds up to gamma-glutamylcysteine to create glutathione a tripeptide important in cellular defense against oxidative stress. It has a molecular mass of approximately 52 kDa. GSH2 shows expression in various tissues with higher levels in the liver and kidneys due to their roles in detoxification processes.
Biological function summary
The role of GSH2 involves maintaining intracellular redox balance and detoxifying harmful substances. GSH2 works closely with glutamate-cysteine ligase in the synthesis of glutathione. As part of the larger antioxidant system GSH2 ensures cells are protected from damage caused by reactive oxygen species.
Pathways
The glutathione synthesis pathway relies heavily on GSH2's activity influencing the glutathione metabolism pathway. This pathway is critical for antioxidant defense and various metabolic processes. GSH2 closely interacts with enzymes like glutathione reductase and glutathione peroxidase emphasizing its importance in maintaining cellular homeostasis.
GSH2 mutations or dysregulation can lead to conditions such as glutathione synthetase deficiency and oxidative stress-related disorders. These conditions often involve impaired glutathione metabolism linking GSH2 to neurological and metabolic dysfunctions. GSH2 mutations affect proteins like catalase and superoxide dismutase resulting in reduced efficiency in combating oxidative stress.