Abcam, ab322066, Anti-CTBS antibody [EPR29368-588] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal antibody. Carrier free. Suitable for mIHC, IHC-P, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29368-588,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:mIHC, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab322066 is the carrier-free version of ab322065.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTBS also known as chitobiase is a lysosomal enzyme that plays a role in the breakdown of chitinous substances. The protein has an approximate mass of 55 kDa. It is expressed mainly in tissues involved in the degradation processes such as the liver kidney and spleen. CTBS facilitates the hydrolysis of chitobiose into its monosaccharide components. This enzymatic activity is important for regulating cellular turnover and recycling materials within the lysosome.
Biological function summary
CTBS participates in the catabolism of glycoproteins and glycolipids contributing to the proper functioning of lysosomal degradation. The protein does not form a part of a complex but functions independently within the lysosome to assist in processing lysosomal storage materials. The activity of CTBS influences cellular homeostasis and the elimination of unnecessary macromolecular structures. Proper CTBS function prevents accumulation of partially degraded molecules that might disrupt cellular operations.
Pathways
The CTBS enzyme acts significantly within the lysosomal degradation pathway. This pathway involves the breakdown and recycling of various biomolecules which is important in maintaining metabolic balance. CTBS interacts with other enzymes like hexosaminidases which further process the breakdown products of its enzymatic activity. The lysosomal degradation pathway plays a role in cellular nutrition and waste elimination ensuring cells receive necessary substrates while disposing of metabolic waste.
CTBS has links to lysosomal storage disorders. These diseases occur when substrates accumulate within the lysosome due to deficient enzymatic activity leading to cellular dysfunction. One notable disorder related to CTBS dysfunction is Sandhoff disease where deficient enzyme activity causes buildup of glycosphingolipids. In this context CTBS is associated with proteins like hexosaminidase A which cooperatively contribute to lysosomal degradation processes. Understanding the role of CTBS in these disorders can help develop therapeutic strategies to manage or treat the conditions associated with lysosomal malfunction.