Abcam, ab32565, Anti-ADAMTS9 antibody

Size: 100µg
Rabbit Polyclonal ADAMTS9 antibody. Suitable for ICC and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS9 aa 650-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADAMTS9 aa 650-700. The exact immunogen used to generate this antibody is proprietary information.Q9P2N4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody is Antigen affinity chromatography purified., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ADAMTS9 protein also known as A Disintegrin and Metalloproteinase with Thrombospondin motifs 9 plays a mechanical role as a metalloproteinase enzyme. It features a molecular weight of approximately 193 kDa. ADAMTS9 is expressed in various tissues including the heart pancreas and kidney among others. This protein undergoes post-translational modifications that impact its mechanical functions offering unique regulation mechanisms for tissue remodeling and extracellular matrix degradation.
Biological function summary
ADAMTS9 influences processes associated with maintaining extracellular matrix integrity and remodeling. It participates in the cleavage of proteoglycans hence modulating cellular environments. This protein does not typically form large complexes but it interacts with substrates that are part of the complex networks found in connective tissues. Its enzymatic activity is subject to intervention by specific inhibitors which can significantly affect tissue homeostasis.
Pathways
ADAMTS9 is involved in the TGF-beta signaling and inflammatory response pathways. The TGF-beta signaling pathway is integral to regulating cellular growth and differentiation. In the inflammatory response ADAMTS9 interacts with proteins like aggrecan playing a part in inflammation-related tissue devastation. These pathways demonstrate the multifunctional nature of ADAMTS9 in cellular and physiological contexts.
ADAMTS9 is notably associated with arthritis and cancer progression. In arthritis the enzymatic activity leads to tissue degradation by breaking down cartilage components linking it to disease progression. In tumors its altered expression may influence cancer cell invasion and metastasis. In these conditions ADAMTS9 interacts with proteins such as versican contributing to pathological changes in tissue architecture and cellular behavior.