Abcam, ab32679, Anti-AKAP9 antibody [17G10]

Size: 100µg
Mouse Monoclonal AKAP9 antibody. Suitable for ICC, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human AKAP9 aa 1-50.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:17G10,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AKAP9 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q99996

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as A-kinase anchor protein 9 (AKAP9) also called Yotiao is involved in the regulation of protein kinase A (PKA). AKAP9 with a mass of approximately 454 kDa is expressed in multiple tissues including the brain heart and muscle tissue. This protein serves as a scaffolding protein that binds PKA to specific subcellular locations thereby organizing the action of signaling enzymes to their target sites.
Biological function summary
AKAP9 plays an essential role in coordinating cellular signaling events. It acts as a hub in a protein complex that includes PKA protein phosphatase 1 and other signaling molecules facilitating targeted signal transduction. It helps regulate ion channel function and the organization of the cell's cytoskeleton. In neurons AKAP9 modulates synaptic signaling and plasticity which influences neurotransmitter release.
Pathways
AKAP9 interacts with signaling pathways such as the cAMP-dependent pathway and calcium signaling. Through these pathways AKAP9 modulates the activity of several related proteins including PKA itself and other proteins like RyR2 a calcium channel. Its involvement in these pathways indicates important roles in regulating cardiac rhythm and other neuronal functions by targeting enzymes to their specific substrates.
AKAP9 has links to cardiac arrhythmias and neurodegenerative disorders. Long QT syndrome linked to aberrant calcium handling involves AKAP9 through its relationship with RyR2 and other cardiac proteins. In Alzheimer's disease the protein's role in synaptic signaling might connect it to amyloid beta and Tau proteins suggesting its involvement in neuronal dysfunction and disease progression.