Abcam, ab33315, Anti-CD151 antibody [11G5a]

Size: 100µg
Mouse Monoclonal CD151 antibody. Suitable for ICC/IF, Flow Cyt and reacts with Human samples. Cited in 18 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:11G5a,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD151 also known as PETA-3 or SFA-1 is a member of the tetraspanin family which are small membrane proteins with molecular mass of about 28 kDa. This protein is commonly expressed on various cells such as epithelial cells endothelial cells and platelets. CD151 is known to interact with integrins especially integrin α3β1 and α6β1 playing significant roles in cell adhesion and migration. It is mostly found in areas where cell-to-cell contact is vital for maintaining tissue integrity and cellular communication.
Biological function summary
CD151 engages in the stabilization of integrin complexes which facilitates signal transduction pathways that influence cellular behaviors like proliferation differentiation and survival. It does not function alone; CD151 is part of a tetraspanin-enriched microdomain (TEM) forming complexes that include proteins such as CD9 CD63 and other integrins. These complexes bring together structural and signaling molecules on the cell membrane creating platforms for efficient signal relay.
Pathways
CD151 plays a role in pathways involving cell adhesion and tissue repair. Notably it is involved in the integrin signaling pathway which is essential for cell-matrix interactions in tissues that require adhesion for repair or restructuring. CD151 interacts with proteins like PI3K and Akt within these pathways which are central to the signaling cascades regulating cellular responses to the extracellular environment.
CD151 participation has been noted in cancer progression and metastasis. It links to the dysregulation observed in integrin functions such as those of integrin α3β1 which directly influences tumor cell invasion and metastasis in cancers like breast and prostate cancer. CD151 also exhibits connections with renal pathologies including Alport syndrome where the lack of functional basement membranes affects kidney function and it interacts with proteins like collagen IV in the disorder's progression.