Abcam, ab3338, Anti-Rabphilin 3A antibody

Size: 100µg
Rabbit Polyclonal Rabphilin 3A antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Rat Rph3a aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Rph3a aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P47709

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rabphilin 3A also known as RPH3A plays a role in exocytosis and synaptic transmission. This protein has a molecular weight of approximately 85 kDa. It contains domains that help in the interaction with small GTPases and phospholipids in the membrane. Rabphilin 3A is expressed in brain tissues particularly in neurons. It associates with synaptic vesicle membranes which is essential for neurotransmitter release at synapses.
Biological function summary
Rabphilin 3A modulates synaptic vesicle docking and fusion in the neuron. It acts as an effector of the small GTPase Rab3 forming a complex that links synaptic vesicles to presynaptic membranes. This interaction influences the dynamics of the membrane and ensures proper vesicle cycling during neurotransmission. Rabphilin 3A also interacts with calcium ions which regulate its affinity for other proteins involved in the synaptic machinery.
Pathways
Rabphilin 3A participates in the regulation of the neurotransmitter release pathway and synaptic vesicle cycle. It interacts with proteins like Rab3A to facilitate vesicle docking and membrane fusion important for synaptic vesicle exocytosis. The cAMP-dependent signaling pathway also involves Rabphilin 3A guiding the processes associated with synapse communication and plasticity.
Rabphilin 3A appears to play a role in neurological disorders like epilepsy and neurodegenerative diseases. Its dysfunction is connected to altered synaptic transmission a factor in epilepsy pathophysiology. Rab3A a protein closely associated with Rabphilin 3A also impacts synaptic activity and their interplay may contribute to understanding diseases affecting synaptic function. Changes in Rabphilin 3A expression or function can lead to imbalances in neurotransmitter release highlighting its potential link to neurodegenerative conditions like Alzheimer's disease.